World class biotechnology toolkit

BRAIN applies a world class biotechnology toolkit to a unique proprietary BioArchive. Our research and development acitivties are driven by a solution focused creative mindset which overcomes single technology limitations. Our toolkit and experience allows us to focus on the challenges that we and our partners face.

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If you would like to talk to us about business opportunities or learn more about our development programs, please contact us.

BioArchive

The BRAIN BioArchive – an industry leading collection of natural resources and metagenome libraries

  • MetXtraTM: unique in silico enzyme selection (Biocatalysts)
  • ABEL®: Activity-Based Expression Libraries (BRAIN)
  • LIL®: Large-Insert Libraries (BRAIN)
  • METAGENO: substantial metagenome libraries (BRAIN)
  • CompActives®: easily scalable compounds for bioactivity screenings (BRAIN)
  • MEGx: world’s most sustainable collection of purified natural products, isolated from plants (MEGxp) and microorganisms (MEGxm) (AnalytiCon Discovery)

Candidate discovery

High-throughput isolation
Extraction and purification of natural products from variable biological resources (AnalytiCon Discovery)

Compound discovery
Activity- and sequence-based screenings for application-driven research incl. biochemical and human cell-based assays

  • screenline®: human cell-based receptor cell lines (BRAIN)

Structure elucidation
Determination of molecular structure of (novel) natural compounds

Sample provision
Rapid production of selected enzyme samples for customer testing

  • Research Grade Sample (RGS): small volume enzyme sample production platform (Biocatalysts)
  • Design for Manufacture (DFM): selection principles of enzyme candidates to maximize the probability for high expression in vivo and production scale-up (Biocatalysts)

Product development

Microbial expression
Large set of pro- and eukaryotic expression strains, termed chassis, for the economic production of enzymes and biocatalysts

Microbial strain development
Tailor-made designer strains based on conventional methodologies, plus engineering novel synthetic pathways and artificial operons for high-value industrial production

Gene and protein engineering
Expression of genes and gene clusters for rationally re-designed production strains, including synthetic biology application, for customized enzymes and biocatalysts with optimized properties

Data evaluation

Analytics
State of the art equipment up to implementation of quality and stability control; covering proteins, metabolites and synthetic compounds

Bioinformatics
Cutting edge bioinformatic technologies enabling the read-out of next generation sequencing (NGS) results, Design Of Experiments (DOE), big data analysis

Production scale-up

Process development
Establishment of up- and downstream processes for efficient and cost-effective microbial production

Process optimization
Identification of optimal parameters for superior production results

Product blending & formulation
Superior knowhow for blending enzymes and formulation of bio-based products

BRAIN Publication

BRAIN Biotechnology Toolkit (overview)

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Technical Paper

Enzyme Discovery: Maximising Success using Nature’s Biodiversity

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Program Teaser

SENSE THE DIFFERENCE – Teaser for TRiP2Application Program

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We are looking for

Job advertisement

Wissenschaftliche/r Mitarbeiter/in (m/w/d), Schwerpunkt: Protein Engineering / Molekularbiologie (in german)

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Selected scientific publications

Towards Novel Bioactive Antiperspirants for Cosmetic Applications

Ertongur-Fauth T., Fischer S, Hartmann D, Brüggemann A, Seeger V, Kleber A, Krohn M (2018) Towards Novel Bioactive Antiperspirants for Cosmetic Applications. IFSCC Magazine, 21 (3), 75-79. This work received the top award in the Applied Research category at the 30th IFSCC Congress in Munich, Germany, September 18-21, 2018.

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Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume‐regulated anion channels

Trothe J., Ritzmann D., Lang V., Scholz P., Pul Ü., Kaufmann R., Buerger C., Ertongur-Fauth T. (2018) Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume-regulated anion channels. Experimental Dermatology, 27, 1352-1360.

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A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium‐activated chloride secretion in human sweat gland epithelial cells

Ertongur-Fauth, T., Hochheimer, A., Buescher, J. M., Rapprich, S. and Krohn, M. (2014), A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Exp Dermatol, 23: 825–831.

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Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology

Simon Huck, Josephine Bock, Jörg Girardello, Marc Gauert & Ümit Pul (2018) Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology, RNA Biology

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Using gas mixtures of CO, CO2 and H2 as microbial substrates

Ralf Takors, Michael Kopf, Joerg Mampel, Wilfried Bluemke, Bastian Blombach, Bernhard Eikmanns, Frank R. Bengelsdorf, Dirk Weuster‐Botz, Peter Dürre. First published: 14 May 2018

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BRAIN BioXtractor: Biobased Metal Extraction for the Circular Economy

Gabor, Esther M. | Hoffmann, Benedikt | Deichmann, Thomas: Industrial Biotechnology, Vol. 14, No. 2, April 2018, Pages 68-73.

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Human cell-based taste perception – a bittersweet job for industry

K. Riedel, D. Sombroek, B. Fiedler, K. Siems and M. Krohn, Nat. Prod. Rep., 2017, Advance Article

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Healthcare Costs Associated with an Adequate Intake of Sugars, Salt and Saturated Fat in Germany

Meier, T., Senftleben, K., Deumelandt, P., Christen, O., Riedel, K., Langer, M., PLOS, September 9, 2015

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