Dr. Dirk Sombroek

Vice President,
Unit Head BioActives & Performance Biologicals
  • Studies of Chemistry (focus on Biochemistry), Albert-Ludwigs-University of Freiburg, Germany
  • Doctorate (Department of Biosciences), Ruprecht-Karls-University Heidelberg
  • Within the framework of the doctorate, graduate of the "Helmholtz International Graduate School for Cancer Research", German Cancer Research Center (DKFZ) Heidelberg
  • Postdoc, DKFZ Heidelberg on these topics: DNA damage response and repair mechanisms, apoptosis and senescence, cancer research

Skills & Expertise

  • Chemistry, biochemistry, cell biology
  • Cell culture (especially higher eukaryotes)
  • Molecular mechanisms of signal transduction and post-translational modifications (esp. phosphorylation and ubiquitination)
  • Human receptor technology
  • Cell-based assay systems and medium-throughput screening (in vitro)
  • Hit validation and mode-of-action analyses
  • Proof-of-concept studies (in vivo)

Dirk at BRAIN

  • Since 2010: Research Scientist and Project Manager, Unit BioActives & Performance Biologicals
  • Since 2015: Platform Coordinator, BioActives Development, Unit BioActives & Performance Biologicals
  • Since 2019: Unit Head BioActives & Performance Biologicals
  • Overall coordination of the Strategic Alliance ”Natural Life Excellence Network 2020“ (NatLifE 2020), funded by the German Federal Ministry of Education and Research (BMBF)

Current fields of activity at BRAIN

  • Responsibility of technology development in the Tech Unit “BioActives & Performance Biologicals”
  • Supervision of BRAIN Biotech’s screening resource (CompActives)
  • Evaluation of chemical structures and structure-activity relationships (SAR)
  • In silico toxicology
  • Application technology and formulation (prototypes)
“I combine my expertise in the chemical properties of substances with my knowledge of the functions of biological systems. In this way, as a BioActives specialist, I make a significant contribution to the targeted development of our innovative active ingredients.”

Contact me via business@brain-biotech.com
or feel free to contact me via LinkedIn.

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