Natural compounds to trigger taste and skin sensations

In the TRiP2Application programs, BRAIN offers unique cell-based assay systems for the identification of novel ingredients for food & cosmetics. In addition, cell models developed by BRAIN enable the development of biological deodorants and aluminum-free antiperspirants.

BRAIN has unique experience in the development of cell models for simulating sweat gland function and other sensory reactions of the skin – known as cell-based assays (CBAs). These assays allow e.g. the simulation of physiological processes in the skin. Based on this expertise BRAIN has teamed up with with scientific partners and developed a new concept to reduce human sweating.

Natural active ingredients that protect against perspiration and body odor are in great demand. These are also sought after as alternatives to products that contain aluminum and pose health risks if used in excess. BRAIN’s research aims at directly influencing primary fluid secretion in human sweat glands using natural compounds from BRAIN’s BioArchive. This scientific achievement received the top award in the “Applied Research” category at the IFSCC Congress 2018.

CBAs are also fueling the TRiP2Application programs TRiP2Taste and TRiP2Sensation which provide access to bio-based ingredients for food and skin care products.

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Listen to Torsten Fauth and his cooperation partners talking about recent results on the emerging role of LRRC8 in human keratinocytes. Source: Virtual Application Day "Nanion & Friends". (C) Nanion Technologies

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The TRiP2 Application...

  • encompasses BRAIN development programs based on unique cell-based assay systems for identifying bio-based ingredients for food and skin care products.
  • includes the TRiP2Taste program aimed at boosting taste sensation.
  • includes the TRiP2Sensation program addressing the development of skin care products.
  • allows measurements of potency, efficacy and cross-selectivity.
  • offers validation options including cross-checks on human cell lines and other molecular targets.

Towards Novel Bioactive Antiperspirants for Cosmetic Applications

Ertongur-Fauth T., Fischer S, Hartmann D, Brüggemann A, Seeger V, Kleber A, Krohn M (2018) IFSCC Magazine, 21 (3), 75-79. This work received the top award in the Applied Research categoryat the 30th IFSCC Congress.

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BRAIN Publication

SENSE THE DIFFERENCE – Teaser for TRiP2Application Program

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BRAIN Publication

Information on TRiP2 Application

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skin care

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10 l

One individual’s sweat glands can produce up to 10 liters of sweat per day.


The skin is our largest organ and weighs about 18 kilograms together with the underlying connective tissue.


Our skin constantly renews itself. We produce an average of 30,000 to 40,000 new skin cells per minute.


So long, sweat!

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