Press releases
10 January 2023, Zwingenberg

BRAIN Group's Akribion Genomics business will prioritize the development of therapeutic applications within its CRISPR technology platform

  • Mode of action suited for applications in oncology
  • Significantly increased addressable market potential
BRAIN Biotech AG today announced its intent to prioritize the development of the genome-editing activities bundled under the brand name Akribion Genomics on therapeutic applications, including applications in oncology. The mode of action of the nucleases selected for this purpose allows both the targeted cell enrichment and depletion by selective disruption. Due to the novel mode of action the nuclease G-dase E™ (previously termed “BEC”) is also primed for applications in therapeutics such as the field of oncology. Michael Krohn, Co-Founder and Co-CEO Akribion Genomics (in founding) states: “The guided toxicity of G-dase E™ allows for targeted cell disruption based on RNA biomarkers. Our technology also has great synergistic potential and will probably also be used to enrich editing efficiency of other more classical CRISPR nucleases that suffer from editing deficiencies.”

Lukas Linnig, Co-Founder and Co-CEO Akribion Genomics (in founding), comments: “This opens up a significantly increased addressable market potential for our proprietary genome-editing platform technology. The next logical step will be to form strong partnerships with companies in the field of cell delivery systems which are going to be critical to address various applications in oncology. We are currently building up our partner network to further enlarge the areas of application.” Adriaan Moelker, CEO BRAIN Biotech AG adds: “The increased focus of Akribion Genomics on therapeutic applications further supports our intention to spin-out our proprietary genome-editing technology (GeditingTM) into the separate legal entity Akribion Genomics. This will allow a better development of applications which go beyond the current core activities of the BRAIN-Group and to attract additional funding for accelerated growth. We will continue to employ the GeditingTM platform for the benefit of all of our customers also in industrial applications.”

On April 4, 2022, BRAIN Biotech had announced demonstrating successfully genome-editing of mammalian cells with its proprietary CRISPR-Cas genome editing nucleases. These BRAIN-developed genome-editing nucleases (G-dasesTM) are already today successfully employed in customer projects within the company´s BioScience division and are utilized for the optimization of highly efficient microbial producer strains which power the biological production in so-called microbial cell factories. The G-dasesTM are currently being advanced for applications in agriculture, therapeutics, marine applications and industrial producer strains.


BRAIN Biotech AG is a leading European supplier of bio-based products and solutions such as enzymes and proteins, microbial production strains, natural compounds and biotechnological solutions for more sustainable industrial processes. The company focuses on the fields of nutrition, health and environment.

BRAIN Biotech AG is the parent company of the international BRAIN Biotech Group. The Group's business activities are divided into three segments: The BioProducts segment comprises the product business with specialty enzymes and other proteins, for which the Group operates fermentation facilities in the United Kingdom and production facilities in continental Europe and the United States. The BioScience segment offers research-intensive custom solutions based on enzyme technology, strain development, bioprocess development and natural product screening. The BioIncubator segment conducts its own R&D projects or those initiated with partners with high value-added potential. A particularly promising incubator project is the development of the Company's own CRISPR-based gene editing technology platform, which is currently being established and expanded by Akribion Genomics (in foundation planning).

Through its own R&D activities, BRAIN Biotech Group is continuously expanding its product portfolio in the field of specialty enzymes and small molecules. The latter are the starting point for screenings, e.g. for novel drug candidates for pharmaceutical applications.

BRAIN Biotech AG has been listed on the Prime Standard of the Frankfurt Stock Exchange since February 9, 2016 (ticker symbol: BNN; securities identification number: ISIN DE0005203947 / WKN 520394). The company employs approximately 330 people and generated revenues of EUR 55,3 million in the fiscal year 2022/23.

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This press release contains forward-looking statements. These statements reflect the current views, expectations, and assumptions of the management of BRAIN Biotech AG, and are based on information currently available to the management. Forward-looking statements are no guarantees of future performance, and entail both known and unknown risks as well as uncertainties that could cause actual results, performance or events to differ materially from those expressed or implied in such statements. Numerous factors exist that could influence the future performance of and future developments at BRAIN Biotech AG and the BRAIN Biotech Group. Such factors include, but are not limited to, changes in the general economic and competitive environment, risks associated with capital markets, currency exchange rate fluctuations, changes in international and national laws and regulations, in particular with respect to tax laws and regulations, as well as other factors. BRAIN Biotech AG does not undertake any obligation to update or revise any forward-looking statements.

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