Dr Dirk Sombroek
is our expert in the field of BioActives & Performance Biologicals
“We are enthusiastic scientists with a wealth of expertise in cell and receptor biology. In addition, we are creative developers of applicable solutions. Our partners benefit from this strong combination.”
The cell-based sensory models (screenlines®) enable BRAIN’s Bioactives team to identify novel active ingredients. We use our assay systems to test large compound libraries (from pure compounds to complex mixtures) for our industrial customers in screening campaigns - for example, pure natural products or fractions from edible plants from the collection held by our subsidiary AnalytiCon Discovery.
Newly identified, promising candidates are characterized with regard to their biological activity: potency and efficacy testing, mode-of-action analysis as well as counterscreens to assess selectivity. This approach supports our industrial partners in the development of new active ingredients for a wide range of applications.
After the identification of new bioactive ingredients in the discovery phase, we also support further evaluation of suitable development candidates in initial proof-of-concept studies for selected applications. Especially in the cosmetics and food sector, BRAIN provides know-how and technical capabilities for the characterization and formulation of active ingredients, including the preparation of product prototypes for efficacy and compatibility studies as well as application testing.
We can draw on a network of external experts and institutions (e.g. toxicologists, safety assessors or formulation specialists) to provide any additional expertise required. Subsidiaries of the BRAIN Group can be involved in the supply of substances and extracts (by AnalytiCon Discovery) or the production of cosmetic products (at L.A. Schmitt). In this way, BRAIN supports partners along the entire value chain, from target to final product.
All software tools are adapted to the respective needs and constantly improved. Our in-house expertise enables a fast and reliable process and immediate adaptation of methods or analysis to results, which makes for highly adaptable and efficient bioinformatics workflows.