Can your enzyme or protein be produced by Aspergillus? We can find out for you

Can your enzyme or protein be produced by Aspergillus? We can find out for you

The sustainable and cost-effective production of proteins is a challenge for manufacturing companies. BRAIN Biotech's "Plug & Produce System" quickly answers the question of whether Aspergillus is the right production strain.

Aspergillus niger (A.niger) is a popular industrial production strain due to its ability to achieve high enzyme production yields. However, only the right combination of target protein and microorganism leads to high production yields and thus to economical production processes. But what is the right combination? This is something that has to be figured out every time, and it costs time and money.

At BRAIN Biotech AG, we are able to produce proteins with double-digit gram per litre yields for both homologous and heterologous proteins. We have plug & produce systems that allow us to quickly check the performance of our production strains. These systems reveal which combination is the most promising starting point.

Due to strong interest from our R&D customers, we have also established this system for A. niger. The expression platform on which the system is based is our industrial A. niger production strain, whose genome allows directed multicopy integration of several "gene expression cassettes" at the same time. This saves our customers development time and money.

Optimization of enzyme production with Aspergillus niger: An efficient system for high yields

Initial situation checked? Take the next step: Develop the production strain

Once we have established the fundamental producibility of the target molecule, we start the specific development of the production strain and the associated production process. We can increase the production yield through molecular biological adaptations of A. niger. The genetic adaptations are targeted and efficient through the use of our proprietary G-dase M® technology.

The BRAIN Biotech Group always takes a holistic approach to microbial strain development. For this reason, we start with process development specific to the corresponding target molecule in parallel to strain development.

How industry can benefit from this system

We offer this technology through our R&D division at the Zwingenberg site, and customers in the fields of enzyme production and precision fermentation in particular can benefit from this platform. With our A.niger production strains and matching fermentation processes, we are able to achieve high production yields for enzymes and proteins. In this way, we help our customers to meet the high demand in various application areas with highly economical production processes.

For more information please contact us

You may also be interested in this

Table fermenters at BRAIN Biotech´s lab in Zwingenberg, Germany
From Pichia to Komagataella: A new name for the same industrial powerhouse
Over many years, we have not only successfully utilized the microbial K. phaffii platform but also further developed it - especially for the industrial production of specialty enzymes. This includes both technical advancements that improve strain performance and product yield, as well as developments addressing regulatory aspects to help accelerate product commercialization.
Read more
View into a lab with table fermenters at BRAIN Biotech´s site in Zwingenberg, Germany
The path to commercially viable production via fermentation
About BRAIN Biotech's services for the scale-up of microbial production. This article provides an insight into their approach and services for fermentation scale-up.
Read more

Contact