The sustainable and cost-effective production of proteins is a challenge for manufacturing companies. BRAIN Biotech's "Plug & Produce System" quickly answers the question of whether Aspergillus is the right production strain.
Aspergillus niger (A.niger) is a popular industrial production strain due to its ability to achieve high enzyme production yields. However, only the right combination of target protein and microorganism leads to high production yields and thus to economical production processes. But what is the right combination? This is something that has to be figured out every time, and it costs time and money.
At BRAIN Biotech AG, we are able to produce proteins with double-digit gram per litre yields for both homologous and heterologous proteins. We have plug & produce systems that allow us to quickly check the performance of our production strains. These systems reveal which combination is the most promising starting point.
Due to strong interest from our R&D customers, we have also established this system for A. niger. The expression platform on which the system is based is our industrial A. niger production strain, whose genome allows directed multicopy integration of several "gene expression cassettes" at the same time. This saves our customers development time and money.
Once we have established the fundamental producibility of the target molecule, we start the specific development of the production strain and the associated production process. We can increase the production yield through molecular biological adaptations of A. niger. The genetic adaptations are targeted and efficient through the use of our proprietary G-dase M® technology.
The BRAIN Biotech Group always takes a holistic approach to microbial strain development. For this reason, we start with process development specific to the corresponding target molecule in parallel to strain development.
We offer this technology through our R&D division at the Zwingenberg site, and customers in the fields of enzyme production and precision fermentation in particular can benefit from this platform. With our A.niger production strains and matching fermentation processes, we are able to achieve high production yields for enzymes and proteins. In this way, we help our customers to meet the high demand in various application areas with highly economical production processes.
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