CRISPR Technology & Licensing

CRISPR Technology & Licensing

Accelerate Strain Development with Tailor-made, Commercial CRISPR Technologies

Bring your next strain development project to market faster. Our proprietary CRISPR technologies enable precise genome editing and targeted cell depletion across diverse organisms, helping you streamline development and accelerate innovation.

Reducing development time and complexity

Whether you are working with bacteria, yeast, fungi, plants, or animal cells, our patented nucleases can help you achieve precise genetic modifications or targeted cell depletion while reducing development time and complexity.

Overcoming challenging bottlenecks in microbial strain development

Do you need a solution tailored to a specific microorganism? Benefit from our more than 30 years of experience in microbiology and genetic engineering. We help to overcome challenging bottlenecks in microbial strain development, from standard bacteria to non-conventional yeasts and fungi.

CRISPR-BMC

Precise genome editing across diverse organisms

Gain easy access to our proprietary CRISPR-BMC technology and expand your genome editing capabilities with licensed access to our patented technology.

BMC® (BRAIN Metagenome Cas) nucleases are metagenomic enzymes available for multiple classes of microorganisms, as well as for plant and animal cell lines. This technology is protected by a granted European substance patent (EP 4 301 852), which provides legal certainty for commercial applications.

Adapt CRISPR-BMC to Your Preferred Production Organism

Are you working with a challenging strain or non-model organism? Our experts can help you adapt the CRISPR-BMC technology to your specific application. We have extensive experience with:

  • Gram-positive bacteria
  • Gram-negative bacteria
  • Industrial yeast strains
  • Filamentous fungi
  • Non-model microorganisms

We can help develop a solution that fits your project, whether you need precise genome editing in an established production strain or a difficult-to-engineer microorganism.

BEC® Nucleases

Targeted cell depletion for special applications

Remove undesired cells with precision

BEC® (BRAIN Engineered Cas) nucleases enable a unique approach to cell population control. These nucleases remain inactive until triggered by a programmable signal. Once activated, they selectively eliminate cells carrying unwanted characteristics, enabling targeted cell depletion within heterogeneous populations.

This unique mechanism was recently described by Scholz et al. (2026, Nature)*.

Unlock new counter-selection possibilities with BEC®

BEC® technology can support applications such as:

  • Depleting phage- or virus-infected cells during bioprocessing
  • Eliminating pest-infested plant seedlings
  • Accelerating the modification of difficult-to-engineer microorganisms

Commercial users can license our patented BEC® technology (EP 4 025 691) through flexible licensing agreements.

Ask about our flexible and clear licensing conditions for BEC® nucleases

BMC or BEC technology?

 

  • Not sure which CRISPR nuclease fits your application?  
     
  • Not sure about the most suitable licensing option? 

Contact us to discuss your application

 

 

* Scholz, P., Thompson, J., Crosby, K.T. et al. RNA-triggered cell killing with CRISPR-Cas12a2. Nature (2026). https://doi.org/10.1038/s41586-026-10466-y

Images:
Header: AI generated; grains: Pixabay; other images (C) BRAIN Biotech AG

 

Note: BMC® and BEC® are EU word marks of BRAIN Biotech AG

Stories

Yeast cells
CRISPR-BMC driven genome editing of robust industrial yeasts
An enzyme engineered version of BRAIN Biotech´s CRISPR-BMC with superior properties in yeasts accelerates development of high-performance strains.
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