World class biotechnology portfolio

BioArchive

The BRAIN BioArchive – an industry leading collection of natural resources and metagenome libraries

• MetXtra^TM: unique in silico enzyme selection (Biocatalysts)
  
• ABEL®: Activity-Based Expression Libraries (BRAIN)
• LIL®: Large-Insert Libraries (BRAIN)
• METAGEN^OM®: substantial metagenome libraries (BRAIN)
• CompActives®: easily scalable compounds for bioactivity screenings (BRAIN)
• MEGx: world’s most sustainable collection of purified natural products, isolated from plants (MEGxp) and microorganisms (MEGxm) (AnalytiCon Discovery)
  

Candidate discovery

High-throughput isolation
Extraction and purification of natural products from variable biological resources (AnalytiCon Discovery)

Compound discovery
Activity- and sequence-based screenings for application-driven research incl. biochemical and human cell-based assays

• screenline®: human cell-based receptor cell lines (BRAIN)
  

Structure elucidation
Determination of molecular structure of (novel) natural compounds

Sample provision
Rapid production of selected enzyme samples for customer testing

• Research Grade Sample (RGS): small volume enzyme sample production platform (Biocatalysts)
• Design for Manufacture (DFM): selection principles of enzyme candidates to maximize the probability for high expression in vivo and production scale-up (Biocatalysts)

Product development

Microbial expression
Large set of pro- and eukaryotic expression strains, termed chassis, for the economic production of enzymes and biocatalysts

Microbial strain development
Tailor-made designer strains based on conventional methodologies, plus engineering novel synthetic pathways and artificial operons for high-value industrial production

Gene and protein engineering
Expression of genes and gene clusters for rationally re-designed production strains, including synthetic biology application, for customized enzymes and biocatalysts with optimized properties

Data evaluation

Analytics
State of the art equipment up to implementation of quality and stability control; covering proteins, metabolites and synthetic compounds

Bioinformatics
Cutting edge bioinformatic technologies enabling the read-out of next generation sequencing (NGS) results, Design Of Experiments (DOE), big data analysis

Production scale-up

Process development
Establishment of up- and downstream processes for efficient and cost-effective microbial production

Process optimization
Identification of optimal parameters for superior production results

Product blending & formulation
Superior knowhow for blending enzymes and formulation of bio-based products