We apply a world class biotechnology portfolio to our unique proprietary BRAIN BioArchive. Our R&D activities are driven by a solution focused creative mindset which overcomes single technology limitations. Our portfolio, in-depth kowledge and long-year experience allows us to focus on the challenges that we and our customers and partners face.
Process development
Establishment of up- and downstream processes for efficient and cost-effective microbial production
Process optimization
Identification of optimal parameters for superior production results
Product blending & formulation
Superior knowhow for blending enzymes and formulation of bio-based products
Analytics
State of the art equipment up to implementation of quality and stability control; covering proteins, metabolites and synthetic compounds
Bioinformatics
Cutting edge bioinformatic technologies enabling the read-out of next generation sequencing (NGS) results, Design Of Experiments (DOE), big data analysis
Microbial expression
Large set of pro- and eukaryotic expression strains, termed chassis, for the economic production of enzymes and biocatalysts
Microbial strain development
Tailor-made designer strains based on conventional methodologies, plus engineering novel synthetic pathways and artificial operons for high-value industrial production
Gene and protein engineering
Expression of genes and gene clusters for rationally re-designed production strains, including synthetic biology application, for customized enzymes and biocatalysts with optimized properties
High-throughput isolation
Extraction and purification of natural products from variable biological resources (AnalytiCon Discovery)
Compound discovery
Activity- and sequence-based screenings for application-driven research incl. biochemical and human cell-based assays
Structure elucidation
Determination of molecular structure of (novel) natural compounds
Sample provision
Rapid production of selected enzyme samples for customer testing
The BRAIN BioArchive – an industry leading collection of natural resources and metagenome libraries
In: E. Guichard and J.L. Le Quéré (Eds), Proceedings of the 16th Weurman Flavour Research Symposium (2021), DOI: 10.5281/zenodo.5574929.
Svenja Siemer, Tobias A Bauer, Paul Scholz, Christina Breder, Federico Fenaroli, Gregory Harms, Dimo Dietrich, Jörn Dietrich, Christine Rosenauer, Matthias Barz, Sven Becker, Sebastian Strieth, Christoph Reinhardt, Torsten Fauth, Jan Hagemann, Roland H Stauber. ACS Nano. 2021 Nov 5. doi: 10.1021/acsnano.1c08632.
Svenja Siemer, Torsten Fauth, Paul Scholz,Y ara Al-Zamel, Aya Khamis, Désirée Gül, Laura Freudelsperger, Barbara Wollenberg, Sven Becker, Roland H. Stauber, and Jan Hagemann. Cancers (Basel). 2021 Sep 27;13(19):4831. doi: 10.3390/cancers13194831
von Molitor E, Riedel K, Krohn M, Hafner M, Rudolf R and Cesetti T (2021) Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation. Front. Hum. Neurosci. 15:667709. doi: 10.3389/fnhum.2021.667709
Magdalena Jahn, Oliver Rauh, Torsten Fauth, Claudia Buerger. Cell Physiol Biochem. 2021 Feb 18;55(S1):57-70. doi: 10.33594/000000330.
Elena von Molitor, Elina Nürnberg, Torsten Ertongur-Fauth, Paul Scholz, Katja Riedel, Mathias Hafner, Rüdiger Rudolf, Tiziana Cesetti. Analysis of Calcium Signaling in Live Human Tongue Cell 3D-Cultures upon Tastant Perfusion. Cell Calcium, 2020, 102164, ISSN 0143-4160
Lars Mathias Blank, Tanja Narancic, Jörg Mampel, Till Tiso, Kevin O’Connor. Biotechnological upcycling of plastic waste and other non-conventional feedstocks in a circular economy, Current Opinion in Biotechnology. Volume 62, 2020. Pages 212-219. ISSN 0958-1669.
Johanna Becker, Hamed Hosseinpour Tehrani, Marc Gauert, Jörg Mampel, Lars M. Blank, Nick Wierckx. An Ustilago maydis chassis for itaconic acid production without by‐products. Microbial Biotechnology (2019) 0(0), 1–13. First published: 27 December 2019
Ertongur-Fauth T., Fischer S, Hartmann D, Brüggemann A, Seeger V, Kleber A, Krohn M (2018) Towards Novel Bioactive Antiperspirants for Cosmetic Applications. IFSCC Magazine, 21 (3), 75-79. This work received the top award in the Applied Research category at the 30th IFSCC Congress in Munich, Germany, September 18-21, 2018.
Trothe J., Ritzmann D., Lang V., Scholz P., Pul Ü., Kaufmann R., Buerger C., Ertongur-Fauth T. (2018) Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume-regulated anion channels. Experimental Dermatology, 27, 1352-1360.
Ertongur-Fauth, T., Hochheimer, A., Buescher, J. M., Rapprich, S. and Krohn, M. (2014), A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Exp Dermatol, 23: 825–831.
Simon Huck, Josephine Bock, Jörg Girardello, Marc Gauert & Ümit Pul (2018) Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology, RNA Biology
Ralf Takors, Michael Kopf, Joerg Mampel, Wilfried Bluemke, Bastian Blombach, Bernhard Eikmanns, Frank R. Bengelsdorf, Dirk Weuster‐Botz, Peter Dürre. First published: 14 May 2018
If you would like to talk to us about business opportunities or learn more about our development programs, please contact us.
