BRAIN Publication
World class biotechnology portfolio
BRAIN applies a world class biotechnology portfolio to a unique proprietary BioArchive. Our research and development acitivties are driven by a solution focused creative mindset which overcomes single technology limitations. Our portfolio and experience allows us to focus on the challenges that we and our partners face.
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BioArchive
The BRAIN BioArchive – an industry leading collection of natural resources and metagenome libraries
- MetXtraTM: unique in silico enzyme selection (Biocatalysts)
- ABEL®: Activity-Based Expression Libraries (BRAIN)
- LIL®: Large-Insert Libraries (BRAIN)
- METAGENOM®: substantial metagenome libraries (BRAIN)
- CompActives®: easily scalable compounds for bioactivity screenings (BRAIN)
- MEGx: world’s most sustainable collection of purified natural products, isolated from plants (MEGxp) and microorganisms (MEGxm) (AnalytiCon Discovery)
Candidate discovery
High-throughput isolation
Extraction and purification of natural products from variable biological resources (AnalytiCon Discovery)
Compound discovery
Activity- and sequence-based screenings for application-driven research incl. biochemical and human cell-based assays
- screenline®: human cell-based receptor cell lines (BRAIN)
Structure elucidation
Determination of molecular structure of (novel) natural compounds
Sample provision
Rapid production of selected enzyme samples for customer testing
- Research Grade Sample (RGS): small volume enzyme sample production platform (Biocatalysts)
- Design for Manufacture (DFM): selection principles of enzyme candidates to maximize the probability for high expression in vivo and production scale-up (Biocatalysts)
Product development
Microbial expression
Large set of pro- and eukaryotic expression strains, termed chassis, for the economic production of enzymes and biocatalysts
Microbial strain development
Tailor-made designer strains based on conventional methodologies, plus engineering novel synthetic pathways and artificial operons for high-value industrial production
Gene and protein engineering
Expression of genes and gene clusters for rationally re-designed production strains, including synthetic biology application, for customized enzymes and biocatalysts with optimized properties
Data evaluation
Analytics
State of the art equipment up to implementation of quality and stability control; covering proteins, metabolites and synthetic compounds
Bioinformatics
Cutting edge bioinformatic technologies enabling the read-out of next generation sequencing (NGS) results, Design Of Experiments (DOE), big data analysis
Production scale-up
Process development
Establishment of up- and downstream processes for efficient and cost-effective microbial production
Process optimization
Identification of optimal parameters for superior production results
Product blending & formulation
Superior knowhow for blending enzymes and formulation of bio-based products
Selected scientific publications
Biotechnological upcycling of plastic waste and other non-conventional feedstocks in a circular economy
Lars Mathias Blank, Tanja Narancic, Jörg Mampel, Till Tiso, Kevin O’Connor. Biotechnological upcycling of plastic waste and other non-conventional feedstocks in a circular economy, Current Opinion in Biotechnology. Volume 62, 2020. Pages 212-219. ISSN 0958-1669.
An Ustilago maydis chassis for itaconic acid production without by‐products
Johanna Becker, Hamed Hosseinpour Tehrani, Marc Gauert, Jörg Mampel, Lars M. Blank, Nick Wierckx. An Ustilago maydis chassis for itaconic acid production without by‐products. Microbial Biotechnology (2019) 0(0), 1–13. First published: 27 December 2019
Towards Novel Bioactive Antiperspirants for Cosmetic Applications
Ertongur-Fauth T., Fischer S, Hartmann D, Brüggemann A, Seeger V, Kleber A, Krohn M (2018) Towards Novel Bioactive Antiperspirants for Cosmetic Applications. IFSCC Magazine, 21 (3), 75-79. This work received the top award in the Applied Research category at the 30th IFSCC Congress in Munich, Germany, September 18-21, 2018.
Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume‐regulated anion channels
Trothe J., Ritzmann D., Lang V., Scholz P., Pul Ü., Kaufmann R., Buerger C., Ertongur-Fauth T. (2018) Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume-regulated anion channels. Experimental Dermatology, 27, 1352-1360.
A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium‐activated chloride secretion in human sweat gland epithelial cells
Ertongur-Fauth, T., Hochheimer, A., Buescher, J. M., Rapprich, S. and Krohn, M. (2014), A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Exp Dermatol, 23: 825–831.
Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology
Simon Huck, Josephine Bock, Jörg Girardello, Marc Gauert & Ümit Pul (2018) Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology, RNA Biology
Using gas mixtures of CO, CO2 and H2 as microbial substrates
Ralf Takors, Michael Kopf, Joerg Mampel, Wilfried Bluemke, Bastian Blombach, Bernhard Eikmanns, Frank R. Bengelsdorf, Dirk Weuster‐Botz, Peter Dürre. First published: 14 May 2018
BRAIN BioXtractor: Biobased Metal Extraction for the Circular Economy
Gabor, Esther M. | Hoffmann, Benedikt | Deichmann, Thomas: Industrial Biotechnology, Vol. 14, No. 2, April 2018, Pages 68-73.