Genome editing has lately become one of the most exciting technologies in biotechnology. It allows for the directed and precise insertion, deletion or modification in the genome of a living organism. The CRISPR-CAS system has provided a genetic tool with speed as well as simplicity that was previously unavailable to science.
BRAIN has developed a novel CRISPR-Cas tool using metagenomics sequencing and protein engineering to isolate a Non-Cas9 genome editing nuclease. Our scientist have achieved this breakthrough employing their expertise and practical R&D experience with genome editing knowledge available throughout the BRAIN Group.
BRAIN’s novel CRISPR associated nuclease has been validated internally as well as with partners and it has demonstrated DNA targeting activity in selected bacteria, fungi and yeast. Activity in plants has been achieved but still needs to be validated. Genome editing tests for additional application fields such as mammalian cell lines have been initiated and a first IP application to protect our nuclease sequence is already submitted.
Dr. Michael Krohn, Head R&D at BRAIN Biotech AG emphasizes: “The market for genome editing tools based on the CRISPR-Cas mechanism is just emerging and offers significant growth opportunities. Our BRAIN developed CRISPR associated nuclease will give us internal freedom to operate and we are currently exploring its potential beyond microorganisms and plants. This success is further evidence of our stated mission to create Breakthroughs. It makes me very proud that the innovative spirit of our scientists keeps creating new projects with real breakthrough potential.”
Adriaan Moelker, CEO BRAIN Biotech AG, comments: “We have stated in the past that we have several projects beyond the feasaibility phase with significant economic potential which might reach maturity to enter our BRAIN Incubator. This project does exactly that. Our BRAIN developed CRISP associated nuclease will enable us to speed up projects for our customers as well as the internal development of high efficiency producer strains. Our next step is to explore and develop appropriate business models to commercialize this exciting technology.”
Lukas Linnig, CFO BRAIN Biotech AG, says: “ We are very pleased by what we have already achieved and currently explore the best business model to further accelerate the development of this exciting genome editing tool. We aim to balance time too market, fields of application, investment requirements and potential partnering with the best interest of our shareholders for value creation.“